Abstract :Nanotechnology has revolutionized all aspects of health including the dentistry. It is the science of producing functional materials and structures in range of 0.1 nm to 100 nm. The most important contribution of nanotechnology to conservative dentistry is the more enhanced restoration of tooth structure with nanocomposites. The field of nanotechnology has tremendous potential, which if harnessed efficiently, can bring out significant benefits to the human society such as improved health, better use of natural resources. The future beholds an era of dentistry in which every procedure will be performed using equipments and devices based on nanotechnology. This article reviews the applications of nanotechnology in Endodontics, Conservative and Preventive dentistry.